At the end of 2006, I fell off a cliff.
It wasn’t a real cliff, but it sure felt like one.
After four years supporting my daughter through a medical crisis that ended up with her surviving a three-organ transplant while also struggling with my own pending divorce, I was done. It felt like I couldn’t take another step.
I knew I was depressed. I had been a practicing psychologist for almost ten years then, and that was the only language I had at the time to describe what I was experiencing.
I was sad and sleepless. I worried all the time, was eating and drinking too much and thought that I would never feel better.
At the suggestions of loved ones, I sought out help. I went to my family doctor and followed his strong recommendation to start an antidepressant and begin therapy.
I kept up the routine of weekly therapy and medication for the better part of the year. I felt somewhat better, but still experienced most of the symptoms listed above and other challenging and persistent issues including: terrible fatigue, brain fog, food allergies, and anxiety that came on when I skipped meals.
When I went to my doctor to see if there was a connection between the new physical symptoms I was having and my depression, he just looked at me puzzled. So did my therapist.
By that time I was pretty frustrated and started searching for answers on the Internet. I had been depressed before, but this was different.
After weeks of research, one term just kept of coming up- Adrenal Fatigue.
I knew I was still depressed (boy had I been through a lot), but reading about Adrenal Fatigue helped explain the combination of physical, mental and emotional symptoms I was experiencing.
As I thought more about it, I wondered if I could be having a depressive reaction to all that I’d been through and also be experiencing the physical consequences of long-term stress.
That way of understanding just seemed right to me.
When I brought my discovery to my care providers, all I got were blank stares again. They had never heard of Adrenal Fatigue and didn’t seem very interested to learn more.
It was at this point I realized I had to find solutions on my own. After much searching, I found an integrative doctor who specialized in Adrenal Fatigue.
More accurately, what we think of as Adrenal Fatigue is known as Hypothalamic-Pituitary-Adrenal Axis (HPA Axis) dysfunction.
The HPA axis is the intricate feedback system between brain and adrenal glands that governs our stress response. Going forward I will continue to refer to the downstream effects of HPA issues as Adrenal Fatigue.
With my integrative doctor’s help, and through specific functional testing, I learned that I did indeed have Adrenal Fatigue and that there were many tools to help me recover. These tools were simple but powerful lifestyle and dietary changes that over time help the adrenal glands mend.
Thus begun my journey to healing….
What are the adrenal glands?
The adrenal glands are part of the endocrine system, located just above your kidneys. They are small in size but produce hormones responsible for many basic life sustaining functions, including but not limited to:
-Converting fats and proteins into energy
-Maintaining normal blood sugar regulation
-Good cardiovascular, GI, and immune functioning
-Post-midlife (menopause in women), production of sex hormones
Through a mental health lens, the adrenals are central to our ability to cope with stress!
They produce two of the body’s main stress-buffering chemicals, the steroid hormones cortisol and adrenaline. Additionally, they make both norepinephrine and epinephrine, two important brain neurotransmitters linked with energy, focus, and depression.
When the adrenals are off, we don’t feel good, and our mood is one of the first things to be affected.
Adrenal glands and stress
Since the adrenal glands’ primary responsibility in the body is to help us cope with stress, high levels of stress over a prolonged period of time can wear down their ability to produce cortisol and other essential hormones.
What stresses the adrenals?
When most of us think about stress, the first thing we think about is psychological stress like I faced. Things like loss of a job, a divorce or a sudden trauma.
But much of the stress that the body faces is physical in nature, often things we are not even aware of like lingering infections, unstable blood sugar or hidden food sensitivities to gluten and dairy. All day, our adrenals are helping us deal with these different kinds of stressors on top of the stress of our daily lives.
So, it’s important to broaden our understanding of stress. The more stressors we have and the longer they last, the more likely our adrenal glands will be affected, and as a result, the worse we will become at handling stress.
And as you will see, this can become a big, big problem.
Stages of Adrenal Fatigue
Adrenal fatigue is more common than you think and it happens with ongoing stress in four progressive stages.
Often we don’t even become aware of this chronic stress condition until we are well into it. I only really woke up to it when the fatigue got so bad my daily functioning was compromised:
Stage 1 (the alarm goes off)
At this stage, high stress has been going on for awhile and the body is able to keep up demand for the stress hormones. At this point, if you had your stress hormones measured, they would likely be high.
Often people in this stage report benefitting from increased arousal and alertness, but some sleep issues may be present as well as intermittent anxiety and tiredness (from fluctuating cortisol).
Stage 2 (the alarm stays on)
In stage 2 your body continues to be able to keep up with hormonal demand, but you start to feel the effects of prolonged stress on your adrenals. People commonly describe the experience of stage 2 as being “wired but tired.” Often including waking up and not feeling rested, being alert on and off during the day, and becoming very fatigued in the afternoon or evening.
In this state, one often experiences frequent anxiety or not being able to settle (remember the physical experience of too much adrenaline is anxiety or panic).
Stage 3 (breakdown)
This is where problems really begin. The adrenals begin to have difficulty buffering all the stress that the body faces.
To adapt to this, the adrenals begin to use up the raw materials slated for sex hormone production. This is commonly referred to as the pregnenolone steal.
As a result, sex hormones like testosterone, estrogen and progesterone begin to drop with increased symptoms.
Typical symptoms include feeling tired much of the time, low mood/lack of enthusiasm, and regular infections.
Stage 4 (burnout)
This is where the body can no longer keep up with chronic stress. Sex hormones, stress hormones and the neurotransmitters norepinephrine and epinephrine are low.
People in this stage usually experience extreme tiredness, irritability, low mood, apathy, and disinterest in the world around them. Hypoglycemia (or low and unstable blood sugar) is an issue at this state, as are chemical sensitivities and food allergies.
Is it Depression or Adrenal Fatigue?
If you look at the symptoms of depression and Adrenal Fatigue, they are virtually the same. It’s pretty clear how you (or the professional you are seeing) might confuse them:
DSM-V Depression Criteria:
-Depressed mood or irritability
-Decreased interest or pleasure
-Changes in appetite
-Changes in sleep
-Fatigue or loss of energy
-Guilt/worthlessness
-Problems with concentration
Psychological Symptoms of Adrenal Fatigue
-Low mood/ irritability
-Low sex drive
-Fatigue
-Loss of motivation
-Self hate
-Poor sleep
-Low self esteem
-Anxiety
There is no doubt that when I entered therapy at my doctor’s strong suggestion, I was suffering from both depression and Adrenal Fatigue. But what do you think the therapist diagnosed me with and treated?
Of course, depression.
Remember, he had never heard of Adrenal Fatigue.
Many people go to a therapist for years or are treated with antidepressants and only get partially better. Could some of them actually have Adrenal Fatigue or a combination of both depression and Adrenal Fatigue?
Practitioners can only diagnose and address what they can see. And they can only see what they have been taught to see.
So, I only had partial healing of my depression symptoms, because only part of my problem was addressed.
I don’t blame the therapist or my family doctor. They were just doing what they knew how to do.
But, I do see this as a problem with our mental health system as a whole. Being part of that system for the last 20 years as a Psychologist, I know the the field lacks a cohesive methodology to understand the ways in which “root’ physical issues can cause or exacerbate mental health symptoms.
In my case what was missed was Adrenal Fatigue. For someone else it might be another physical trigger like food allergies or autoimmunity.
So why don’t most medical providers or psychotherapists know about adrenal fatigue?
Adrenal Fatigue is a controversial topic within mainstream medical circles.
What doctors learn in medical school is that there is only one adrenal deficiency disorder, which is called Addison’s disease. It’s a serious condition, which affects 4 out of every 100,000 people and is treated with lifelong steroid replacement.
Without treatment, Addison’s is a debilitating condition. Multiple systems in the body fail and stress buffering is rendered impossible.
But, if Addison’s is the only “real” adrenal deficiency disorder, what about all of the people experiencing symptoms of Stage 3 or 4 Adrenal Fatigue?
Unfortunately, these folks are NOT diagnosed or treated until they get bad enough to reach the threshold of Addison’s. In fact, most of these folks are labeled, often wrongly, as psychiatric cases, because their blood work comes back normal, and there is no way to understand their symptoms through a mainstream medical lens.
So, it’s no wonder that antidepressants and therapy were what was offered to me. There was no doubt that I needed therapy, but I needed a broader medical understanding as well.
How do you know if Adrenal Fatigue is contributing to your depression?
If you have been depressed for a while and have not responded fully to psychotherapy and/or medication (and especially if you have had prolonged periods of illness or life stressors), I would strongly suggest finding an integrative practitioner to help you understand whether Adrenal Fatigue is contributing to your depressive symptoms.
Here are a few databases to find qualified practitioners in your area with knowledge of mental health issues and physical root causes:
–Integrative Medicine For Mental Health
In addition, I do phone consults around the world to help you identify and work with the “root” causes of your depression, including Adrenal Fatigue. To set up an initial phone consult click here.
My next blog will be on what to do next if you are depressed and find out that you have adrenal fatigue. Stay tuned…
If you like this post and want to hear more information about the “root cause” of depression, sign up for my email list. As a bonus, you’ll get my FREE “Nutrition For Mental Health Guidebook”.
In good (mental) health,
Dr. Josh
Dr. Josh Friedman has more than 25 years experience in mental health as a client, psychologist, and functional nutrition practitioner. After working in the field for a few years, he realized how many people were still struggling with depression and other mental health issues even after years of therapy and medication. Over time he became increasingly uncomfortable with the limitations of standard psychiatric treatment and knew there had to be a better way. Over the past decade and a half, he has committed himself to learning as much as he could about the root causes of mental health symptoms. To share this information and to help people get unstuck, he started Alternative Mental Health Solution.
Great article! This underlies the importance of encouraging our clients to have regular physicals and seek out integrative/holistic providers.
Thanks so much Maria. To me, it makes sense for underlying physical causes of mental health symptoms be ruled out in EVERY case. I know this is not currently standard of care but in the near future it really should be.
Hi Dr. Friedman,
I have been dealing with anxiety related symptoms for the past year and a half. Before the stressors of work and relationships, I used to have a big appetite and be able to sleep 10+ hours without any issues along with consistent strength training. Throughout this past year, I have had to deal with various reactions that seemed to change with time. It started with digestive issues and general anxiety that escalated to panic attacks. Then brain fog persisted for a couple months, then blurry vision for a month, to reduced appetite and general anxiety throughout the day. I quit coffee outright as it would spark panic and anxiety. I learned to manage those symptoms through exercise and Sam E / other vitamins. I was initially worried about the panic attacks but they subsided and barely occur anymore. The blurry vision went away too but the general anxiety persisted along with periodic changes in appetite. After moving back to my home city, my symptoms got a little better and I felt a little like my old self but I started getting these odd episodes of overwhelming fatigue that I never felt before. I found that I would get it after an intense workout or drinking session that would last for a couple days. But it was random. I then started noticing this adrenaline rush I would get as soon as I wake up that would keep my from falling asleep again. Any idea on where this is coming from? Could this be an adrenal failure or related to blood sugar? Or is this just general anxiety?
Thank you!
Sounds like your adrenals are definitely a part of it! Have you had a 4 sample saliva test done to look at cortisol output? That would be a place to start. Also, what happens with fatigue or anxiety if you go too long between meals (like more that 4-5 hours w/o food)? If symptoms are worse when skipping meals would def suggest a blood sugar component which would tax your adrenals.
Hi, I am a 55 year old woman who in the past few years has been diagnosed with adrenal exhaustion stage from hair mineral analysis and saliva tests. I have had some level of depression since I was a child and I realize family stress must have played a part in it though I suspect my adrenals were weak from birth. Since I have had 2 failed marriages and my kids are now grown, the loneliness and isolation I feel are almost unbearable and anxiety has increased. I’ve only recently realized that I must have been anxious since childhood too. It is some comfort to finally understand why my life has been so disappointing and full of fear, but instead of hope, I feel discouraged because healing seems so elusive at my age and even if I could find the right doctor to help me, the cost is prohibitive. I’ve been to 2 different doctors using different protocols. One doctor ruined my life by giving me pregnenolone and dhea which made me more sick. But is good to read from someone who seems to understand some of what I’m going through.
Thanks for sharing Tresa. It can be so daunting to find the right answers. I would encourage you to keep trying. Adrenal issues are usually a signal that there is some deeper imbalance going on. things like blood sugar issues, GI dysbiosis, food allergies. I do hope that you are able to find a practitioner that can help you sort out the underlying triggers in a supportive and cost effective way. I will be sending healing energy your way
Yes, I’ve had low blood sugar also from a young age, I have memories of episodes at maybe 4 or years old. I thought this was a symptom of adrenal fatigue, not a cause?
I can be both a symptom of AF and a cause of it as well.
Hi Dr.Josh,
i have been suffering from postpartum depression 8 months ago now, and have been under cipralex for that. But i don,t feel good yet just a little better.
i am pretty sure i am dealing with adrenal fatigue. so i ‘ve done some research and changed my diet based on what i’ve found. At the moment Gluten free and no processed food. Do you think i also need Vitamin c supplements? How long does it take to treat adrenal fatigue i’ve read it needs at leat 6 months?
I am also wondering what are the costs of a consultation with you? do you also provide a diet plan?
Thanks
Najwa
The first thing I would suggest doing is have your zinc and copper levels checked. High copper is the most common cause of postpartum depression. If it is high copper will need to address this to support your adrenals. Would be good to do a saliva test that tests cortisol, DHEA and your sex hormones. This will give you an idea whether the imbalance is hormonal or copper.
Hi doctor. I would be glad for some help on solving my issues.
I’ve always been anxious/little bit depressed.
I’ve been gone thru a bad time after taking Ciprofloxacin, which has left me
with many side-effects, even today.
Since then, my pre-existing adrenal fatigue only got worse, and my mood
is getting worse also.
After some stressful period, I’m feeling very anxious and more depressed as usual.
Seems like by the end of the night I get feeling better and less depressed.
Do you think this mood issues have something to do with the adrenal fatigue?
If yes, how can I start to treat it?
Best regards,
Ricardo Reis
Hi Ricardo,
Mood issue can be caused by adrenal fatigue for sure. First thing I would do would be to get your adrenal glands tested using a 4 sample salivary test. Biohealth and Diagnostech’s both have reasonably priced and good tests. If your symptoms were made worse after taking cypro I would assume that gut issues are part of your problem. Testing would help to identify if you have overgrowth of bad bacteria and the health of your GI tract. You can start with adrenal support (I would stick to adaptogens like Ashwaghanda, Holy Basil, and Rhodiola as they will help whether your adrenals are producing too much or too little cortisol) and a good broad spectrum probiotic. I like Therbiotic Complete by Klaire Labs.
Best
Dr. Josh
Hi Dr Josh
Ive been diagnosed with adrenal fatigue as well, its been a though journey and Im still no where near the finnishline (or so im feeling). Ive read alot about the condition and have been having ups and downs because of it. Reading other’s struggle and seeing how medical practitioners disregard this condition. Im in a point where I feel like everything is going downhill, I cannot function properly eventhough I am seeking treatment I still have times of self doubt that I am getting better. Reading your blog has given me a bit of hope that somebody understands, although its though I know I will get there. How long before you felt like there was an improvement in your condition? It would really mean alot to me to know as ive been struggling not knowing when this will end.
Thanks for sharing Tin. I know it can be a long road. I have been and continue on it. It can take several years to recover fully. Have you had your adrenals tested using either the DUTCH test or saliva testing. Healing is a combination of supporting the adrenals through supplements/lifestyle change as well as identifying the underlying physical triggers and addressing those. This last piece is probably the most important and often neglect piece of the puzzle.
Thank you for replying Dr Josh I have not tried those tests, but did others. What are examples of the physical triggers? Maybe I have missed them. Thank you
The kinds of physical triggers include things like inflammation, food sensitivities, GI infections like bacteria, parasites or yeast, heavy metals and others..
Ive been diagnosed with heartburn, might be the physical cause that I am missing.
Heartburn can be an indication of GI issues like bacterial overgrowth with organisms like H.Pylori. A stool tests would the way to identify which bacteria. parasites or yeast are stressing your adrenals. It is impossible to really get traction on adrenal healing without finding the “hidden stressors”!